Furthermore, an N0147 trial assessing the potential benefit from cetuximab treatment combined with FOLFOX in patients with resected stage III CRC showed that the three-year disease-free survival in patients with wild-type KRAS was significantly better than that in patients with KRAS mutants (72.3% versus 64.2%, HR = 0.7, p = 0.004) (Table 1). Here, KRAS is linked to colorectal carcinoma.