Furthermore, a recent retrospective analysis by De Roock et al., examined 579 patients with chemotherapy-refractory CRC who received cetuximab treatment, and revealed that patients with p.G13D-mutated tumors showed a trend toward a higher response rate than other KRAS-mutated tumors (6.3% versus 1.6%, p = 0.15). The gene discussed is KRAS; the disease is colorectal carcinoma.