To further explore the potential feasibility of RPL6 as gene therapy target of gastric cancer in clinic, we knocked down RPL6 expression in SGC7901 and AGS cells by RPL6-specific siRNA, results showed that down-regulation of RPL6 in gastric cancer parental cell lines (SGC7901 and AGS) effectively inhibited cell growth and in vitro colony forming ability. Here, RPL6 is linked to gastric cancer.