Further research demonstrated that down-regulation of RPL6 by RPL6-specific siRNA inhibited the proliferation and anchorage-independent growth of gastric cancer cell lines in vitro, repressed cell cycle progression and suppressed cyclin E expression, Moreover, knockdown of RPL6 by RPL6-specific siRNA suppressed tumor formation ability of gastric cancer cells in vivo. The gene discussed is RPL6; the disease is gastric cancer.