OIP5 and cancer: Among them, a representative chromosome regions were located on the chromosome 15.1, which were enriched by a number of up-regulated carcinogenesis-related genes, such as OIP5, a potential cancer therapeutic target [50], and PAK6, a member of the p21-activated kinase (PAK) family of serine/threonine kinases, may play roles in the regulation of cell motility and in stress responses [51].