Regarding tuberculosis (TB), randomized clinical trials (RCTs) conducted in resource-limited settings [14]–[17] suggest that early cART (initiated during the first 15 days) may lead to benefit among HIV-infected, cART-naïve patients with TB, at least for those with the greatest level of immunosuppression (baseline CD4+ T cells <50 cells/mm3). Here, CD4 is linked to tuberculosis.