TOP1 and viral infectious disease: We observed a number of factors in the innate response that have been shown to play important roles for the viral infection of the target cell, factors that are involved in HIV-1 endocytosis, nuclear import, integration, transcription, nuclear export and inhibition of antiviral factors (e.g. AGFG1, AP2B1, CUL5, HIVEP1, IPO7, KPNA1, KPNA5, KPNA6, KPNB1, PML, SMAD3, SMAD4, SP1, SUPT4H1, TAF8, TOP1, XRCC6).