We observed a number of factors in the innate response that have been shown to play important roles for the viral infection of the target cell, factors that are involved in HIV-1 endocytosis, nuclear import, integration, transcription, nuclear export and inhibition of antiviral factors (e.g. AGFG1, AP2B1, CUL5, HIVEP1, IPO7, KPNA1, KPNA5, KPNA6, KPNB1, PML, SMAD3, SMAD4, SP1, SUPT4H1, TAF8, TOP1, XRCC6). Here, AP2B1 is linked to viral infectious disease.