We observed a number of factors in the innate response that have been shown to play important roles for the viral infection of the target cell, factors that are involved in HIV-1 endocytosis, nuclear import, integration, transcription, nuclear export and inhibition of antiviral factors (e.g. AGFG1, AP2B1, CUL5, HIVEP1, IPO7, KPNA1, KPNA5, KPNA6, KPNB1, PML, SMAD3, SMAD4, SP1, SUPT4H1, TAF8, TOP1, XRCC6). This evidence concerns the gene SMAD4 and viral infectious disease.