Although previous reports demonstrated caspase-3 activation in a mouse model of PD with MPTP treatment [40], [41], [42], human PD brain samples [43], [44], and in vitro models with 6-OHDA [16], [45], [46], [47], there is no report demonstrating caspase-3 activation in a mouse or rat model of striatal 6-OHDA injection in vivo[25]. This evidence concerns the gene CASP3 and Parkinson disease.