Although these pathogenic factors cause diabetic cardiomyopathy, probably via a different mechanism [16, 19-23], their major contribution to diabetic cardiomyopathy is oxidative stress [24], which is derived directly from these pathogenic factors or indirectly from metabolic intermediates caused by these factors, such as the formation of AGEs and production of cytokines or peptides, such as angiotensin II (AT-II). Here, AGT is linked to diabetic cardiomyopathy.