Also, activation of HIF-1 by pharmacological or siRNA mediated inhibition of prolyl hydroxylase resulted in significant reduction in myocardial infarct size and expression of chemokines like MIP-2, KC, monocyte chemoattractant protein-1 and ICAM-1, implicating HIF 1 in modulating I/R-associated cardiac inflammatory responses [125]. This evidence concerns the gene HIF1A and myocardial infarction.