Additionally, the recent development of arrayed primer extension (APEX) technology can be used as an efficient and cost-effective first pass screening tool for known single base substitutions, deletions and insertions in ALMS1 and for 10 known genes causing a similarly related disorder, Bardet-Biedl syndrome (BBS) (Asper Biotech (www.asperbio.com)) [11]. The gene discussed is ALMS1; the disease is Bardet-Biedl syndrome.