The accuracy of DNI for differentiating between the presence and absence of severe sepsis/septic shock was higher than those of other laboratory markers (p < 0.001 for DNI vs. WBC; p = 0.002 for DNI vs. ANC; p = 0.02 for DNI vs. lactate; and p = 0.009 for DNI vs. CRP). Here, CRP is linked to Sepsis.