Genes for small molecular biochemistry (oxidation, metabolism, and transport reactions of acids, vitamins, and hormones) and lipid and nucleic acid metabolisms (e.g., Cyp1a1, Slco1a5, Fabp1) and cell morphology (e.g., Cdkn1a, Cxcl9) were modulated in common during the early tumorigenesis stage (12 wk) and in UN tissues at 22 wk (Figure 5A) suggesting similar molecular events are taking place in early neoplasia and in the tumor microenvironment. The gene discussed is CDKN1A; the disease is neoplasm.