However, a recent study found that experimentally implanted lung cancer cells (Lewis lung carcinomas) produced significantly more pulmonary metastatic nodules in Nrf2-/- than in Nrf2+/+mice, while the metastatic nodule formation was suppressed in Keap1-knockdown mice compared to Keap1 normal mice [29]. The gene discussed is NFE2L2; the disease is lung carcinoma.