The densitometric analysis of overall staining for expression of both MR and GR in LA/BLA showed an increase in H animals as compared to E rats (t6 = 4.904, p = 0.003; Figure 4D and t6 = 2.880; p = 0.028; Figure 4G, respectively), suggesting that MR and GR mRNA expression are upregulated in adult-onset hypothyroidism. The gene discussed is NR3C2; the disease is hypothyroidism.