To get more insights into the intracellular mechanism by which S-diclofenac upregulated the cardiac expression of connexins in doxorubicin-induced cardiomyopathy, further experiments were performed to investigate the effect of S-diclofenac on JNK activation, known to play a part in modulating the connexin expression [13]–[16]. Here, MAPK8 is linked to cardiomyopathy.