SELE and neoplasm: In this process, endothelial selectin (E-selectin), which is upregulated by IR both on the level of the mRNA and protein [19], [20], is of particular importance [7], [21] as it mediates the interaction of the endothelium with tumor cells that specifically express sialylated carbohydrate structures operating as E-selectin ligands [21], [22], [23], [24], [25].