The second recurrently involved region on 1p36 (patients 121 and 149), was found between probes RP11-56N19 and RP11-929P4, an interval of 722 kb which contains, among others, TNFRSF8 (a positive regulator of apoptosis) and TNFRSF1B. In patient 149 (a MF), we identified the partner locus as HMGA2 on 12q14.3 using break-apart probes RP11-125M17 and RP11-427K2, suggesting a novel partner locus on 1p36 for this multi-partner gene whose disruption and aberrant expression has been observed in various myeloid malignancies [27]. The gene discussed is HMGA2; the disease is myeloid neoplasm.