PRKCZ is a putative oncogene, as it encodes a member of a family of serine/threonine kinases involved in proliferation, differentiation and secretion [41], while RERE may be a a putative tumor suppressor gene because of its involvement in the control of cell survival [42] and because it is the most centromeric locus disrupted in 3 cases of unbalanced rearrangements (cases 044, 113 and 102, i.e. respectively 1 LPS, 1 AML and 1 FL). The gene discussed is PRKCZ; the disease is acute myeloid leukemia.