MYC and lymphoma: The functional role of ribosomal biogenesis in Myc-mediated tumorigenesis has been established through the effects of Rpl24 heterozygosity on Eμ-Myc lymphomagenesis [25], [50], where Eμ-Myc;Rpl24+/− mice have reduced spleen sizes, delayed lymphoma development and prolonged survival compared to their Eμ-Myc;Rpl24+/+ littermates.