MYC and cancer: This Myc core signature is conserved from Drosophila to man and reveals a primordial function of MYC involving ribosomal biogenesis, consistent with both the nucleolar hypertrophy observed in ESCs and cancer [23], [24], [25] and with small cell and body sizes of adult Drosophila diminutive mutant flies having hypomorphic dMyc alleles that phenocopy loss of ribosomal protein function in Drosophila[26].