The expression of FBP1 was significantly upregulated in liver cancer cell lines HepG2, BEL-7402, SMMC-7721, Sk-Hep1, MHCC-97H and MHCC-97L (6/9, 66.7%) after Aza treatment (Figure 1B) and also in colon cancer cell lines HT29, SW620, LoVo and RKO (4/6, 66.7%) (Figure 1B), indicating that FBP1 is likely downregulated through promoter hypermethylation in human liver and colon cancer. This evidence concerns the gene FBP1 and malignant colon neoplasm.