We had to determine FBP1 expression and methylation status in only 10 pairs of primary HCCs, 5 pairs of gastric tumor tissues and 5 pairs of colon tumor tissues (Figure 3), suggesting that FBP1 functions as a novel tumor suppressor candidate downregulated through promoter hypermethylation in liver and colon cancer. Here, FBP1 is linked to colonic neoplasm.