For instance, hypoxic preconditioning of cardiac stem/progenitor cells (cardiosphere-derived, Lin− c-kit+ progenitor cells) upregulates CXCR4 expression and increases the recruitment of these cells into the ischemic myocardium, thereby reducing the infarct size and improving the cardiac function after MI [9]. The gene discussed is CXCR4; the disease is myocardial infarction.