In the EPIC-Norfolk subcohort excluding participants with incident T2D (final n with available genotype = 650), each copy of the C allele of rs198389 was associated with an increase of 0.23 SD (95% CI 0.12–0.34, p<0.001) in log-transformed NT-pro-BNP levels. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.