NPPB and type 2 diabetes mellitus: The association between the variant rs198389 and risk of T2D expected from the NT-pro-BNP to T2D association and the difference in NT-pro-BNP levels per rs198389 allele was similar to that observed in T2D case-control studies, and instrumental variable analysis suggested an effect size of genetically increased NT-pro-BNP levels on risk for T2D consistent with that found in the ordinary regression analysis of observational cohort studies.