As in CdLS, and in Nipbl-heterozygous mice [21], Nipbl-deficient fish also exhibit growth retardation and distinctive craniofacial abnormalities (Figures 2C and S5), the latter including severe reductions of the hyosymplectic cartilage, the homologue of the mammalian stapes [70]. This evidence concerns the gene NIPBL and Cornelia de Lange syndrome.