More recently, we constructed a bicistronic adenoviral vector expressing the GFP-TRAIL fusion protein from the hTERT promoter via GAL4 gene regulatory system (Ad/gTRAIL) and demonstrated that Ad/gTRAIL treatment effectively elicited apoptosis in various tumor cells in vitro and suppressed xenograft tumor growth in vivo, with no detectable toxicity in human primary hepatocytes [10]. This evidence concerns the gene LGALS4 and neoplasm.