High levels of proinflammatory cytokines, including IL-1b and tumor necrosis factor-alpha (TNF-a), and low levels of cytokines which suppress the immunoinflammatory response, such as IL-10 and transforming growth factor-b (TGF-b), have been detected in periodontitis as well as in Rheumatoid Arthritis [9]. The gene discussed is TNF; the disease is rheumatoid arthritis.