In FMS compared to controls:IL-1β, IL-2, IL-6, IL-8, IL-10, sIL-2R, IFNγ, TNF: ↔ in sera +PBMCIL-1RA: ⇑ in serumIL-8: ⇑ in plasma IL-1 RA, IL-6: ⇑ in PBMCIL-6: ⇑ in PBMC of patients with disease duration > 2 years. This evidence concerns the gene TNF and rheumatoid arthritis.