Our recent study also demonstrated that the detection of 53BP1 NF by immunofluorescence can be a useful histological marker with which to estimate the malignant potential of thyroid and skin tumours.15,16 Thus, we propose that immunofluorescence analysis of 53BP1 expression can be a useful tool with which to estimate the level of GIN and, simultaneously, the stage of cancerous progression of uterine cervical lesions. The gene discussed is TP53BP1; the disease is thyroid gland disorder.