Similar results, showing the differences in 53BP1 expression patterns during carcinogenesis, were obtained in our previous studies on thyroid and skin tumours resected from patients.15,16 Therefore, we propose that immunofluorescence analysis of 53BP1 expression can be a useful tool with which to estimate the level of GIN as well as the malignant potential of several human tumours. The gene discussed is TP53BP1; the disease is neoplasm.