CASP3 and neoplasm: To determine whether the magnitude of caspase 3/7 cleaved CK18 corresponded with tumour burden, we compared circulating M30 antigen levels from dulanermin-treated mice (60 mg kg−1) with established Colo205 tumours of variable size (either 50, 125 or 225 mm3 at time of dosing) 24 h after dosing.