Cytokeratin 18 increases have also been reported in response to doxorubicin treatment of FaDu head and neck carcinoma xenografts, and following treatment of SW620 colon carcinoma xenografts with the Aurora kinase inhibitor AZD1152 (Cummings et al, 2008; Olofsson et al, 2009). Here, KRT18 is linked to head and neck carcinoma.