The main results of the meta-analysis were as follows: ANP infusion significantly decreased peak serum creatinine levels, incidence of arrhythmia and need for renal replacement therapy (Figure 2), and ANP or BNP infusion significantly decreased the length of ICU stay and hospital stay compared with controls, but not mortality compared with controls (Figures 3 and 4). The gene discussed is NPPA; the disease is cardiac arrhythmia.