Mochizuki et al. demonstrated inhibition of NOX4 activates apoptosis via the Akt/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells [20], but apoptosis was not observed in urothelial carcinoma cells by NOX4 knockdown, unlike in NOX1 gene silencing [14]. Here, MAP3K5 is linked to familial pancreatic carcinoma.