Interestingly, HIF-1α and HPV16 E7 immunoreactivity were uniform in location on the same tumor (Figure 1A and 1C), and their labeling indexes showed a significantly positive correlation (Rho = .512; p < .001), which suggested a positive association between HPV16 E7 and HIF-1α expression (Figure 4). The gene discussed is HIF1A; the disease is neoplasm.