However these findings have not been confirmed by other reports (2,5,15,18,20). Among Italian studies, no association has been reported between ACE I/D polymorphism and AD (14,18,20), even if Palumbo et al. showed an increased frequency of D allele in subjects with cognitive impairment (14). In the present study, we investigated the role of ACE I/D polymorphism in a group of sAD patients. The gene discussed is ACE; the disease is Alzheimer disease.