CNR1 and neuropathic pain: Recent studies also demonstrated that the activation of CB1R stimulates the cGMP production in neuronal cells [14], that the antinociceptive effects produced by a CB1 endocannabinoid are mainly mediated by the nitric oxide-cGMP pathway activation [15] and that the inactivation of the nitric oxide-cGMP-PKG peripheral pathway enhanced the peripheral antinociceptive effects of CB2R agonists during neuropathic pain [16].