The results demonstrate that allele-specific RNAi is possible for the α-synuclein A30P and LRRK2 G2019S PD-linked mutations, with alignments p10, p13, p14 and p1314 best for the A30P mutation and p4 best for the G2019S mutation, but that the success of this approach is highly dependent on the nature of the mutation. Here, LRRK2 is linked to Parkinson disease.