BRD2 and cartilage-hair hypoplasia: These pattern of response to pulsatile GnRH treatment are different from those reported in hypothalamic CHH patients, where GnRH leads to a rise in FSH, sometimes to supraphysiologic levels [26], further underlining the originality of the TAC3/TACR3 mutated nCHH patients' neuroendocrine phenotype.