These pattern of response to pulsatile GnRH treatment are different from those reported in hypothalamic CHH patients, where GnRH leads to a rise in FSH, sometimes to supraphysiologic levels [26], further underlining the originality of the TAC3/TACR3 mutated nCHH patients' neuroendocrine phenotype. This evidence concerns the gene GNRH1 and cartilage-hair hypoplasia.