These genetic disorders include LPL -/- [16], apoE 2/2 [17], apoE 4/4 [17], homozygous familial hypercholesterolemia [19], homozygous familial defective apoB [29], and S447X [30] - a single nucleotide polymorphism in the LPL gene. The gene discussed is APOE; the disease is familial hypercholesterolemia.