Anti-TPO was positive in 25.3% (41/162) of patients with T1DM and 3.7% (3/80) of controls, p < 0.001, anti-Tg was positive in 47.5% (77/162) of patients and 6.2% (5/80) of controls, p < 0.001 [Figure 1]. The gene discussed is TG; the disease is type 1 diabetes mellitus.