TARDBP and amyotrophic lateral sclerosis: TDP-43M337V mice exhibited certain features similar to those seen in ALS, such as TDP-43 cleavage, phosphorylation, aggregation, increased ubiquitination, gliosis, gait disturbances, and early lethality; however, the mice also exhibited other features not yet reported in humans, which may be due to the effect of hTDP-43M337V overexpression.