Our preliminary in silico analysis found that both miR-101 and miR-494 may target SEC24 3’-UTR and two other genes, TGFB1 and MBL2, which are known to modify the development and/or the severity of lung disease in CF [2], suggesting the existence of a coordinated network of gene expression control by microRNAs. The gene discussed is SEC24B; the disease is cystic fibrosis.