CYP2J2 and hypertensive disorder: CYP2J2 in particular has a number of vascular protective properties including protection of hypoxia-reoxygenation endothelial injury [12], decreased cytokine-induced cell adhesion molecule expression by inhibition of NFκB [8], reduction of inflammatory cell recruitment [13], and the reduction of hypertension and hypertension induced-renal injury [14] and smooth muscle migration [15].