LGALS1 and cancer: For example, tri- and tetraantennary N-glycans bind galectin-3 to increase cell surface residence time of epidermal growth factor receptors in cancer cells, in turn increasing cell sensitivity and growth response to EGF [6], [17], and by analogous mechanisms, galectin-1 regulates cell surface expression of integrins [18], in turn affecting tumour cell adhesion and migration, and cell surface expression of the calcium channel TRPV5, in turn affecting Ca-homeostasis [19].