IDO1 and infection: In addition, in contrast to the observed for others intracellular pathogens which are sensitive to Trp starvation, we have previously demonstrated that T. cruzi Am and Tps are sensitive to the Kyn downstream metabolite 3-HK, and the therapeutic administration of 3-HK (1 mg/kg/day, intraperitoneally) during the acute phase of the infection decreased the parasitemia and improved the survival of lethally infected mice [17], suggesting that the pharmacologic intervention of IDO pathway could be used as a novel antitrypanosomatid therapeutic strategy.