CXCL8 and cystic fibrosis: In agreement with previous findings [44], THP-1 monocytes stimulated with LPS extracted from P. aeruginosa strains isolated from chronically-infected lungs of CF patients secreted higher amounts of IL-8 than cells stimulated with commercially available P. aeruginosa LPS at comparable concentrations demonstrating heightened activation of pro-inflammatory responses which is associated with more highly acylated forms of P. aeruginosa LPS.