A2M and hydrops fetalis: In the LV myocardium 20 days after Dox administration, DNA microarray analysis revealed a high upregulation of established HF markers/risk factors, with a significant fold change ranging from 4.06 (alpha-2-macroglobulin) to 27.81 (resistin) in Dox-injected as compared to PBS-injected piglets (Table 3).