The moderate reduction (60–70%) of ventricular myocd activity observed in these experiments did not lead to any deterioration of cardiac function in neonatal piglets, as one could have expected from previous studies, where cardio-restricted myocd knockdown (85%) was found to induce dilated cardiomyopathy and fatal HF in postnatal mice [17]. Here, MYOCD is linked to dilated cardiomyopathy.