ESRRA and hydrops fetalis: HS-NT rats presented signs of myocardial metabolic disorders with reduced oxidative capacity, CS activity and miCK content, and a global downregulation of genes involved in mitochondrial biogenesis such as PGC-1α, ERRα and their downstream target genes, similar to numerous HF models including DSS rats [8]–[10], [12], [34], [34], [39,40].