In fact, the hippocampus is one of the regions to suffer brain damage in Alzheimer's disease, and a recent study showed that transcranial laser therapy using an 808-nm laser diode attenuated amyloid plaque development in the transgenic mouse model with mutant amyloid- precursor protein, implying the possible efficacy of this therapeutic strategy for Alzheimer's disease [54]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.