This conclusion is also in agreement with the observations that GATA5 DNA methylation is a common marker for both types of esophageal cancers, EAC and esophageal squamous cell carcinoma (ESCC) [30], as well as for three different types of lung cancers that each have distinct cells of origin [33]. The gene discussed is GATA5; the disease is esophageal squamous cell carcinoma.