The available protein structure of HBB gene showed PDB ID: 4HHB and HBB mutations showing β-Hemoglobinopathies on the ß-chain were following (1) HbC β6; AA Glu→Lys (E→K), (2) HbD β121; AA Glu→Gln (E→Q), (3) HbE β26; Glu→Lys (E→K), and (4) HbS β6; Glu→Val (E→V). This evidence concerns the gene KRT88P and hemoglobinopathy.