As shown in Figure 3, C and D, neither caspase-4 nor caspase-3 were activated by target siRNAs in NCI-H929 MM cells while pharmacological death inducers promoted cleavage of caspase-4 (tunicamycine) and caspase-3 (staurosporine) in the same cells. Here, CASP3 is linked to Miyoshi myopathy.