CRH and preterm premature rupture of the membranes: Recent data have reported that, in human placentas from women with PPROM and chorioamnionitis, inflammatory events are associated with changes to the CRH-related mechanism of labor, such as increased CRH, UCN 2, and CRH-R1 mRNA expression and decreased UCN 3 and CRH-R2 expression [73].