NFKB1 and multiple sclerosis: Imbalance of NF-κB and IκBα has been associated with development of common inflammatory diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson's disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer, hepatocellular carcinoma, breast cancer, and myeloma.