Higher percentage of IκBα+ and NF-κB+/IκBα+ cells were found in CIA mice under polymerized-type I collagen and methotrexate/polymerized-type I collagen treatment in early arthritis in the first and second sacrifice compared with CIA mice without treatment (Figures 5(a) and 5(b)). Here, NFKBIA is linked to arthritic joint disease.