Imbalance of NF-κB and IκBα has been associated with development of common inflammatory diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson's disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer, hepatocellular carcinoma, breast cancer, and myeloma. This evidence concerns the gene NFKBIA and type 1 diabetes mellitus.