We tested the influence of systemic application of CpG or LMS on antitumor effect induced by DNA vaccines delivered with a gene gun in two mouse tumor models: TC-1 cells producing the HPV16 E7 oncoprotein and 12B1 cells producing the BCR-ABL1 fusion protein injected s.c. into C57BL/6 and BALB/c mice, respectively. This evidence concerns the gene ABL1 and neoplasm.