As TP53 mutation represents one of the very early event in the development of high-grade serous carcinoma, it is currently not clear if DNA damage occurs before or after TP53 mutations, although it has been suggested that activation of Chk2 and other DDR members may precede p53 inactivation in human epithelial tumors [22, 38]. The gene discussed is CHEK2; the disease is serous adenocarcinoma.