In this study, we address three main questions: whether there is a difference in the level of DDR between high-grade and low-grade serous carcinoma; whether recurrent high-grade serous carcinomas have an altered DDR as compared to their primaries; whether there is a significant correlation in the expression levels between pChk2 and Rsf-1 (HBXAP), a gene that is frequently upregulated in high-grade serous carcinoma and participates in generating DNA damage. This evidence concerns the gene RSF1 and serous adenocarcinoma.